Q’UMARA

El concepto de vida saludable es cada vez más común entre los jóvenes y adultos en el Perú, lo cual va relacionada con una mejor alimentación. Según estudios que se realizaron en las puertas de clínicas, muchas personas que siguen este estilo de vida buscan evitar una gran enfermedad, el Cáncer. A pesar que esta no es la primera causa de muerte, sino los paros cardiacos, el tratamiento es doloroso y conllevarlo es difícil, por lo cual muchas personas buscan formas sobre cómo evitarlo. De esta forma, los autores de este proyecto investigaron que los frutos oscuros y el yogurt mitigan la aparición de células cancerígenas. Por ello, se creó el emprendimiento de Q’umara, el cual ofrece un yogurt natural con toppings de frutos oscuros totalmente orgánicos. En el presente informe se detallarán el público objetivo y los planes que se llevarán al cabo para que la realización de este proyecto sea exitosa. Se necesitará un capital de 44690 nuevos soles y levantar fondos por 25940 nuevos soles para completar la inversión. Cabe resaltar que los indicadores de este proyecto son llamativos; por ejemplo, el VAN es de 46163 nuevos soles. Por otra parte, el periodo de recupero será en el mes 21.20. Además, el indicador de beneficio costo será de 4.39. Por ello, esperamos convencer a los inversionistas con esta gran idea de negocio.This project was born from the idea that healthy lifestyle is becoming more popular in Peru, which is related to healthy food. According to results of studies that were carried out at the doors of clinics, many people who follow this lifestyle seek to avoid a major disease, Cancer. Although this is not the first cause of death, the treatments are very painful and ruins quality of life This is where 5 students from Universidad Peruana de Ciencias Aplicadas realized that people seek to prevent cancer through their diet. So, they researched about what kind of food could prevent this disease and the results were thar dark fruits and yogurt mitigate the appearance of cancer cells. For this reason, Q’umara was created, which offers a natural yogurt with totally organic dark fruit toppings. This report will detail the target and the plans that will be carried out to make this project successful. A capital of 44690 nuevos soles will be needed. However, as shareholders, a part of these will be placed, but it will be necessary to raise funds for 25,940 nuevos soles to complete the investment. Indicators of this project are very attractive. For example, the Net Present Value discounted with the WACC is 46163 nuevos soles. On the other hand, the recovery period will be in month 21.20. In addition, the cost benefit indicator is 4.39. With these indicators we want to show the potential of this project.Trabajo de investigació

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

New technologies and their relationship on competitiveness in traditional neighborhood stores in the city of Huancayo, 2021

El presente trabajo de investigación se enfoca en determinar la relación de las nuevas tecnologías con la competitividad en bodegas y minimarkets tradicionales de la ciudad de Huancayo en 2021. Con la consigna de lograr el objetivo, se hizo una revisión exhaustiva de la literatura sobre conceptos teóricos relacionados a la digitalización y el manejo de las nuevas herramientas digitales como factores competitivos que afectan a las pequeñas empresas. El diseño de la investigación es no experimental, correlacional y de corte trasversal debido a que se recogieron datos en un determinado tiempo. Respecto a la recolección de información para el análisis, se realizó una encuesta cuantitativa de tipo Likert a bodegueros de forma presencial a una muestra de 90 bodegas elegidas de manera aleatoria. La información recopilada de las fuentes bibliográficas e integrado al trabajo de campo obtenido mediante las encuestas, han permitido conseguir información sobre la tecnología y su relación con la competitividad en bodegas tradicionales, ello para validar las hipótesis planteadas en el presente estudio. Finalmente, con la información obtenida, ha sido posible demostrar que los medios digitales de pago y plataformas digitales tienen relación con la competitividad de bodegas y minimarkets como factor de diferenciación.This research work focuses on determining the relationship of new technologies on the competitiveness of traditional neighborhood stores and minimarkets in the city of Huancayo in 2021. With the aim of achieving the objective, a comprehensive review of the literature on concepts was carried out on theoretical concepts related to digitization and management of new digital tools as competitive factors that affect small businesses. The research design is non-experimental, correlational, and cross-sectional since data was collected in a certain time. Regarding the collection of information for the analysis, a quantitative Likert-type survey was carried, shopkeepers were surveyed face-to-face with a sample of 90 randomly chosen traditional neighborhood stores. The information collected from biographical sources in conjunction with field work through surveys have made it possible to obtain information on technology and its relationship with competitiveness in neighborhood stores, this to validate the hypotheses proposed in this study. Finally, with the information obtained, it was found that digital payment and digital platforms are related to the competitiveness of neighborhood store as a differentiating factor.Tesi

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially

Global economic burden of unmet surgical need for appendicitis

Background There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US $92 492 million using approach 1 and$73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was $95 004 million using approach 1 and$75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially